Functional assessment of microbial superoxide dismutase isozymes suggests a differential role for each isozyme.
Identifieur interne : 000510 ( Main/Exploration ); précédent : 000509; suivant : 000511Functional assessment of microbial superoxide dismutase isozymes suggests a differential role for each isozyme.
Auteurs : Hastyar Najmuldeen [Iraq] ; Rashed Alghamdi [Royaume-Uni] ; Fayez Alghofaili [Arabie saoudite] ; Hasan Yesilkaya [Royaume-Uni]Source :
- Free radical biology & medicine [ 1873-4596 ] ; 2019.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Biofilms (croissance et développement), Femelle (MeSH), Infections à Klebsiella (microbiologie), Klebsiella pneumoniae (croissance et développement), Klebsiella pneumoniae (enzymologie), Klebsiella pneumoniae (génétique), Mutation (MeSH), Partie nasale du pharynx (microbiologie), Protéines bactériennes (classification), Protéines bactériennes (génétique), Protéines bactériennes (métabolisme), Souris (MeSH), Souris de lignée BALB C (MeSH), Stress oxydatif (MeSH), Superoxide dismutase (classification), Superoxide dismutase (génétique), Superoxide dismutase (métabolisme).
- MESH :
- classification : Protéines bactériennes, Superoxide dismutase.
- croissance et développement : Biofilms, Klebsiella pneumoniae.
- enzymologie : Klebsiella pneumoniae.
- génétique : Klebsiella pneumoniae, Protéines bactériennes, Superoxide dismutase.
- microbiologie : Infections à Klebsiella, Partie nasale du pharynx.
- métabolisme : Protéines bactériennes, Superoxide dismutase.
- Animaux, Femelle, Mutation, Souris, Souris de lignée BALB C, Stress oxydatif.
English descriptors
- KwdEn :
- Animals (MeSH), Bacterial Proteins (classification), Bacterial Proteins (genetics), Bacterial Proteins (metabolism), Biofilms (growth & development), Female (MeSH), Klebsiella Infections (microbiology), Klebsiella pneumoniae (enzymology), Klebsiella pneumoniae (genetics), Klebsiella pneumoniae (growth & development), Mice (MeSH), Mice, Inbred BALB C (MeSH), Mutation (MeSH), Nasopharynx (microbiology), Oxidative Stress (MeSH), Superoxide Dismutase (classification), Superoxide Dismutase (genetics), Superoxide Dismutase (metabolism).
- MESH :
- chemical , classification : Bacterial Proteins, Superoxide Dismutase.
- chemical , genetics : Bacterial Proteins, Superoxide Dismutase.
- chemical , metabolism : Bacterial Proteins, Superoxide Dismutase.
- enzymology : Klebsiella pneumoniae.
- genetics : Klebsiella pneumoniae.
- growth & development : Biofilms, Klebsiella pneumoniae.
- microbiology : Klebsiella Infections, Nasopharynx.
- Animals, Female, Mice, Mice, Inbred BALB C, Mutation, Oxidative Stress.
Abstract
Microbes can have multiple enzymes that are able to catalyse the same enzymatic reactions but may differ in structure. These are known as isozymes. It is assumed that isozymes have the same functional role for cells. Contrary to this assumption, we hypothesised that isozymes can confer different functions for microbial cells despite catalysing the same reactions. To test this hypothesis, we studied the role of superoxide dismutases (SOD) in Klebsiella pneumoniae, the causative agent of several nosocomial and community-acquired infections, in infection relevant assays. SODs are responsible for detoxification of toxic superoxide radicals. K. pneumoniae genome contains three superoxide dismutase genes, sodA, sodB, and sodC coding for Mn-, Fe- and CuZn- co-factored SODs, respectively. By creating and testing single, double, and triple SOD mutants, we investigated the regulatory interactions among SOD and determined the role of each isozyme in oxidative stress resistance, biofilm formation, cell morphology, metabolism, and in vivo colonization and persistence. Our results demonstrate that SOD isozymes in K. pneumoniae have unique roles beyond oxidative stress resistance, and there is a regulatory interplay among SODs.
DOI: 10.1016/j.freeradbiomed.2019.01.018
PubMed: 30658083
Affiliations:
Links toward previous steps (curation, corpus...)
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Electronic address: hy3@le.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Infection, Immunity and Inflammation, University of Leicester, University Road, Leicester LE1 9HN</wicri:regionArea><wicri:noRegion>Leicester LE1 9HN</wicri:noRegion></affiliation></author></analytic><series><title level="j">Free radical biology & medicine</title><idno type="eISSN">1873-4596</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Bacterial Proteins (classification)</term><term>Bacterial Proteins (genetics)</term><term>Bacterial Proteins (metabolism)</term><term>Biofilms (growth & development)</term><term>Female (MeSH)</term><term>Klebsiella Infections (microbiology)</term><term>Klebsiella pneumoniae (enzymology)</term><term>Klebsiella pneumoniae (genetics)</term><term>Klebsiella pneumoniae (growth & development)</term><term>Mice (MeSH)</term><term>Mice, Inbred BALB C (MeSH)</term><term>Mutation (MeSH)</term><term>Nasopharynx (microbiology)</term><term>Oxidative Stress (MeSH)</term><term>Superoxide Dismutase (classification)</term><term>Superoxide Dismutase (genetics)</term><term>Superoxide Dismutase (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Biofilms (croissance et développement)</term><term>Femelle (MeSH)</term><term>Infections à Klebsiella (microbiologie)</term><term>Klebsiella pneumoniae (croissance et développement)</term><term>Klebsiella pneumoniae (enzymologie)</term><term>Klebsiella pneumoniae (génétique)</term><term>Mutation (MeSH)</term><term>Partie nasale du pharynx (microbiologie)</term><term>Protéines bactériennes (classification)</term><term>Protéines bactériennes (génétique)</term><term>Protéines bactériennes (métabolisme)</term><term>Souris (MeSH)</term><term>Souris de lignée BALB C (MeSH)</term><term>Stress oxydatif (MeSH)</term><term>Superoxide dismutase (classification)</term><term>Superoxide dismutase (génétique)</term><term>Superoxide dismutase (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="classification" xml:lang="en"><term>Bacterial Proteins</term><term>Superoxide Dismutase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Bacterial Proteins</term><term>Superoxide Dismutase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Bacterial Proteins</term><term>Superoxide Dismutase</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="fr"><term>Protéines bactériennes</term><term>Superoxide dismutase</term></keywords><keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Biofilms</term><term>Klebsiella pneumoniae</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Klebsiella pneumoniae</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Klebsiella pneumoniae</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Klebsiella pneumoniae</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Biofilms</term><term>Klebsiella pneumoniae</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Klebsiella pneumoniae</term><term>Protéines bactériennes</term><term>Superoxide dismutase</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Infections à Klebsiella</term><term>Partie nasale du pharynx</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Klebsiella Infections</term><term>Nasopharynx</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protéines bactériennes</term><term>Superoxide dismutase</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Mutation</term><term>Oxidative Stress</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Mutation</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Stress oxydatif</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Microbes can have multiple enzymes that are able to catalyse the same enzymatic reactions but may differ in structure. These are known as isozymes. It is assumed that isozymes have the same functional role for cells. Contrary to this assumption, we hypothesised that isozymes can confer different functions for microbial cells despite catalysing the same reactions. To test this hypothesis, we studied the role of superoxide dismutases (SOD) in Klebsiella pneumoniae, the causative agent of several nosocomial and community-acquired infections, in infection relevant assays. SODs are responsible for detoxification of toxic superoxide radicals. K. pneumoniae genome contains three superoxide dismutase genes, sodA, sodB, and sodC coding for Mn-, Fe- and CuZn- co-factored SODs, respectively. By creating and testing single, double, and triple SOD mutants, we investigated the regulatory interactions among SOD and determined the role of each isozyme in oxidative stress resistance, biofilm formation, cell morphology, metabolism, and in vivo colonization and persistence. Our results demonstrate that SOD isozymes in K. pneumoniae have unique roles beyond oxidative stress resistance, and there is a regulatory interplay among SODs.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30658083</PMID><DateCompleted><Year>2020</Year><Month>03</Month><Day>26</Day></DateCompleted><DateRevised><Year>2020</Year><Month>03</Month><Day>26</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-4596</ISSN><JournalIssue CitedMedium="Internet"><Volume>134</Volume><PubDate><Year>2019</Year><Month>04</Month></PubDate></JournalIssue><Title>Free radical biology & medicine</Title><ISOAbbreviation>Free Radic Biol Med</ISOAbbreviation></Journal><ArticleTitle>Functional assessment of microbial superoxide dismutase isozymes suggests a differential role for each isozyme.</ArticleTitle><Pagination><MedlinePgn>215-228</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0891-5849(18)31677-0</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.freeradbiomed.2019.01.018</ELocationID><Abstract><AbstractText>Microbes can have multiple enzymes that are able to catalyse the same enzymatic reactions but may differ in structure. These are known as isozymes. It is assumed that isozymes have the same functional role for cells. Contrary to this assumption, we hypothesised that isozymes can confer different functions for microbial cells despite catalysing the same reactions. To test this hypothesis, we studied the role of superoxide dismutases (SOD) in Klebsiella pneumoniae, the causative agent of several nosocomial and community-acquired infections, in infection relevant assays. SODs are responsible for detoxification of toxic superoxide radicals. K. pneumoniae genome contains three superoxide dismutase genes, sodA, sodB, and sodC coding for Mn-, Fe- and CuZn- co-factored SODs, respectively. By creating and testing single, double, and triple SOD mutants, we investigated the regulatory interactions among SOD and determined the role of each isozyme in oxidative stress resistance, biofilm formation, cell morphology, metabolism, and in vivo colonization and persistence. Our results demonstrate that SOD isozymes in K. pneumoniae have unique roles beyond oxidative stress resistance, and there is a regulatory interplay among SODs.</AbstractText><CopyrightInformation>Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Najmuldeen</LastName><ForeName>Hastyar</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Infection, Immunity and Inflammation, University of Leicester, University Road, Leicester LE1 9HN, UK; Department of Biology, College of Science, University of Sulaimani, Sulaymaniyah, Kurdistan Region, Iraq.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alghamdi</LastName><ForeName>Rashed</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Infection, Immunity and Inflammation, University of Leicester, University Road, Leicester LE1 9HN, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alghofaili</LastName><ForeName>Fayez</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Infection, Immunity and Inflammation, University of Leicester, University Road, Leicester LE1 9HN, UK; Department of Biology, College of Science, Majmaah University, Majmaah 11952, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yesilkaya</LastName><ForeName>Hasan</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Infection, Immunity and Inflammation, University of Leicester, University Road, Leicester LE1 9HN, UK. Electronic address: hy3@le.ac.uk.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>01</Month><Day>15</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Free Radic Biol Med</MedlineTA><NlmUniqueID>8709159</NlmUniqueID><ISSNLinking>0891-5849</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001426">Bacterial Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.15.1.1</RegistryNumber><NameOfSubstance UI="D013482">Superoxide Dismutase</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001426" MajorTopicYN="N">Bacterial Proteins</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018441" MajorTopicYN="N">Biofilms</DescriptorName><QualifierName UI="Q000254" MajorTopicYN="Y">growth & development</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007710" MajorTopicYN="N">Klebsiella Infections</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007711" MajorTopicYN="N">Klebsiella pneumoniae</DescriptorName><QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000254" MajorTopicYN="Y">growth & development</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008807" MajorTopicYN="N">Mice, Inbred BALB C</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009154" MajorTopicYN="N">Mutation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009305" MajorTopicYN="N">Nasopharynx</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018384" MajorTopicYN="Y">Oxidative Stress</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013482" MajorTopicYN="N">Superoxide Dismutase</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Biofilm</Keyword><Keyword MajorTopicYN="Y">Cell morphology</Keyword><Keyword MajorTopicYN="Y">Isozymes</Keyword><Keyword MajorTopicYN="Y">Klebsiella pneumoniae</Keyword><Keyword MajorTopicYN="Y">Lung infection</Keyword><Keyword MajorTopicYN="Y">Mucoviscosity</Keyword><Keyword MajorTopicYN="Y">Oxidative stress resistance</Keyword><Keyword MajorTopicYN="Y">Persistence</Keyword><Keyword MajorTopicYN="Y">Superoxide dismutase</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>09</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2018</Year><Month>12</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>01</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>1</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>3</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>1</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30658083</ArticleId><ArticleId IdType="pii">S0891-5849(18)31677-0</ArticleId><ArticleId IdType="doi">10.1016/j.freeradbiomed.2019.01.018</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Arabie saoudite</li><li>Iraq</li><li>Royaume-Uni</li></country></list><tree><country name="Iraq"><noRegion><name sortKey="Najmuldeen, Hastyar" sort="Najmuldeen, Hastyar" uniqKey="Najmuldeen H" first="Hastyar" last="Najmuldeen">Hastyar Najmuldeen</name></noRegion></country><country name="Royaume-Uni"><noRegion><name sortKey="Alghamdi, Rashed" sort="Alghamdi, Rashed" uniqKey="Alghamdi R" first="Rashed" last="Alghamdi">Rashed Alghamdi</name></noRegion><name sortKey="Yesilkaya, Hasan" sort="Yesilkaya, Hasan" uniqKey="Yesilkaya H" first="Hasan" last="Yesilkaya">Hasan Yesilkaya</name></country><country name="Arabie saoudite"><noRegion><name sortKey="Alghofaili, Fayez" sort="Alghofaili, Fayez" uniqKey="Alghofaili F" first="Fayez" last="Alghofaili">Fayez Alghofaili</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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